Technoeconomic Evaluation of Multiple Mixed Suspension-Mixed Product Removal (MSMPR) Crystallizer Configurations for Continuous Cyclosporine Crystallization
نویسندگان
چکیده
منابع مشابه
Simulation of Continuous Preferential Crystallization Processes
This work investigates the effects of different seeding strategies and residence time characteristics on the dynamics of a Mixed Suspension Mixed Product Removal (MSMPR) crystallizer equipped with a fines dissolution unit and applied to continuous preferential enantioselective crystallization. The fines dissolution is included as recycle streams around the MSMPR crystallizer. Moreover, primary ...
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The separation of enantiomers is of great importance due to their possible differences in therapeutic properties. Preferential crystallization in various configurations of coupled batch crystallizers is used as an attractive means to separate the conglomerate-forming enantiomers from racemic mixtures. However, the productivity of such batch processes can be limited by the nucleation of the coun...
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ژورنال
عنوان ژورنال: Organic Process Research & Development
سال: 2017
ISSN: 1083-6160,1520-586X
DOI: 10.1021/acs.oprd.7b00225